Article
Synergism and complementarity between human CD1 AND MHC-restricted T cells, two lymphoid subsets directed against distinct antigenic worlds.
Frontiers in bioscience : a journal and virtual library - 1 Jan 2005
Bonneville Marc, Scotet Emmanuel
Abstract excerpt
The antigenic repertoire of T cells has long been considered as exclusively composed of proteins and peptides. This view has been recently challenged by the discovery of CD1 molecules, a set of weakly polymorphic MHC class I-related receptors able to present lipid antigens to T cells. An updated picture of the biology of human CD1-restricted T cells is provided here, which highlights the unique features of these...
Topics
- Animals
- Antigens
- Antigens, CD1
- Autoimmunity
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Dendritic Cells
- Histocompatibility Antigens
- Humans
- Killer Cells, Natural
- Lipids
