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Article

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins

23 Apr 2013

Abstract excerpt

Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved αβ T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the MHC related-1 (MR1) protein. MAIT cells are dependent upon MR1 expression and exposure to microbes for their development and stimulation, yet these cells can exhibit microbial-independent stimulation when responding to MR1 from different species. We...

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PMID: 23613577
DOI: 10.1073/pnas.1222678110

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