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Article

A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1+ TCRs.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018

Guo Tingxi, Koo Ming Yin, Kagoya Yuki, Anczurowski Mark, Wang Chung-Hsi, Saso Kayoko, Butler Marcus O, Hirano Naoto

Abstract excerpt

In humans, a substantial portion of T cells recognize lipids presented by the monomorphic CD1 proteins. Recent studies have revealed the molecular basis of mycobacterial lipid recognition by CD1c-restricted T cells. Subsets of CD1c-restricted T cells recognize self-lipids in addition to foreign lipids, which may have implications in human diseases involving autoimmunity and malignancy. However, the molecular...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29237773
DOI: 10.4049/jimmunol.1700677
PMCID: PMC5760327

Genes

APC
CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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