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Article

Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials.

Science advances - 8 Dec 2023

Vantourout Pierre, Eum Josephine, Conde Poole María, Hayday Thomas S, Laing Adam G, Hussain Khiyam, Nuamah Rosamond, Kannambath Shichina, Moisan Jacques, Stoop Allart, Battaglia Sebastiano, Servattalab Roya, Hsu Jonathan, Bayliffe Andrew, Katragadda Madan, Hayday Adrian C

Abstract excerpt

Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex (MHC), MR1, or CD1 proteins underpin adaptive immunity. Those responses are mostly mediated by complementarity-determining region 3 motifs created by quasi-random T cell receptor (TCR) gene rearrangements, with diversity being highest for TCRγδ. Nonetheless, TCRγδ also displays nonclonotypic innate responsiveness following...

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Identifiers

PMID: 38055824
DOI: 10.1126/sciadv.adj6174
PMCID: PMC10699787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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