Article
Divergent function of polycystin 1 and polycystin 2 in cell size regulation.
Biochemical and biophysical research communications - 8 Jan 2020
Viau Amandine, Kotsis Fruzsina, Boehlke Christopher, Braeg Simone, Klein Marinella, Nitschke Roland, Walz Gerd, Kuehn E Wolfgang
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2, the genes encoding polycystin 1 (PC1) and polycystin 2 (PC2), respectively. PC1 and PC2 localize to the primary cilium and form a protein complex, which is thought to regulate signaling events. PKD1 mutations are associated with a stronger phenotype than PKD2, suggesting the existence of PC1 specific functions in renal...
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