Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Mechanisms of ADPKD.

Advances in experimental medicine and biology - 1 Jan 2016

Kim Do Yeon, Park Jong Hoon

Abstract excerpt

Autosomal dominant polycystic kidney disease is caused by mutation of PKD1 (polycystic kidney disease-1) or PKD2 (polycystic kidney disease-2). PKD1 and PKD2 encode PC1 (polycystin-1) and PC2 (polycystin-2), respectively. In addition, the mutation of cilia-associated proteins is also a recognized major factor of pathogenesis, since PC1 and PC2 are located in primary cilium. Abnormalities of PC1 or PC2 lead to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PKD1 gene
Share to PKD2 gene
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polycystic Kidney, Autosomal Dominant

Share to Signal Transduction

Share to TRPP Cation Channels

Source

Identifiers

PMID: 27730431
DOI: 10.1007/978-981-10-2041-4_2

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Mechanisms of ADPKD.PMID 27730431Read ↗

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.Semantic proximity Read ↗

Genetics and Pathogenesis of Polycystic Kidney DiseaseSemantic proximity Read ↗

Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2).Semantic proximity Read ↗

Molecular Pathophysiology of Autosomal Recessive Polycystic Kidney Disease.Semantic proximity Read ↗

Insights Into the Molecular Mechanisms of Polycystic Kidney DiseasesSemantic proximity Read ↗

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney DiseaseSemantic proximity Read ↗

Physiologic mechanisms underlying polycystic kidney disease.Semantic proximity Read ↗

Pilot Study of the Occurrence of Somatic Mutations in Ciliary Signalling Pathways as a Contribution Factor to Autosomal Dominant Polycystic Kidney Development.Semantic proximity Read ↗

Synergistic Genetic Interactions between Pkhd1 and Pkd1 Result in an ARPKD-Like Phenotype in Murine ModelsSemantic proximity Read ↗

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Renal Pathology of CiliopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.