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Article

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.

Nature genetics - 1 Feb 2003

Nauli Surya M, Alenghat Francis J, Luo Ying, Williams Eric, Vassilev Peter, Li Xiaogang, Elia Andrew E H, Lu Weining, Brown Edward M, Quinn Stephen J, Ingber Donald E, Zhou Jing

Abstract excerpt

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (encoding polaris). It is not known, however, whether ciliary dysfunction occurs or is relevant to cyst formation in...

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PMID: 12514735
DOI: 10.1038/ng1076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12514735-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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