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The cell biology of polycystic kidney disease

15 Nov 2010

Abstract excerpt

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease, which is attributable to mutations in the PKD1 and PKD2 genes and which is characterized by perturbations of renal epithelial cell growth control, fluid transport, and morphogenesis. The mechanisms that connect the underlying genetic...

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PMID: 21079243
DOI: 10.1083/jcb.201006173

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