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Article

Polycystins and partners: proposed role in mechanosensitivity.

The Journal of physiology - 15 Jun 2014

Retailleau Kevin, Duprat Fabrice

Abstract excerpt

Mutations of the two polycystins, PC1 and PC2, lead to polycystic kidney disease. Polycystins are able to form complexes with numerous families of proteins that have been suggested to participate in mechanical sensing. The proposed role of polycystins and their partners in the kidney primary cilium is to sense urine flow. A role for polycystins in mechanosensing has also been shown in other cell types such as...

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Identifiers

PMID: 24687583
DOI: 10.1113/jphysiol.2014.271346
PMCID: PMC4080931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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