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Emerging evidence of a link between the polycystins and the mTOR pathways

28 Oct 2009

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by the formation of renal cysts. This disease can be caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC-1) and -2 (PC-2), respectively.PC-1 is a large plasma membrane receptor involved in the regulation of several biological functions and signaling pathways, and PC-2 is a calcium channel of the TRP...

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PMID: 19863783
DOI: 10.1186/1755-8417-2-6

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