Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiologic mechanisms underlying polycystic kidney disease.

Physiological reviews - 1 Jul 2025

Boletta Alessandra, Caplan Michael J

Abstract excerpt

Polycystic kidney disease (PKD) encompasses a class of disorders presenting with bilateral cyst formation in the kidney. PKD can be inherited as a dominant (ADPKD) or a recessive (ARPKD) trait, due to mutations into multiple genes, the most frequent being PKD1, PKD2, and PKHD1. The protein products of these genes (polycystin-1, polycystin-2, and fibrocystin, respectively) have been shown to reside within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cilia
Share to PKD1 gene
Share to PKD2 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to PKHD1 gene

Share to Kidney

Share to Mutation

Share to Polycystic Kidney Diseases

Share to TRPP Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 39938884
DOI: 10.1152/physrev.00018.2024
PMCID: PMC12174308

Genes

PKD1
PKD2
PKHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiologic mechanisms underlying polycystic kidney disease.PMID 39938884Read ↗

Polycystic Kidney DiseaseSemantic proximity Read ↗

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.Semantic proximity Read ↗

Genetics and Pathogenesis of Polycystic Kidney DiseaseSemantic proximity Read ↗

Polycystic liver and kidney diseasesSemantic proximity Read ↗

Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney DiseaseSemantic proximity Read ↗

Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2).Semantic proximity Read ↗

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.Semantic proximity Read ↗

Renal Pathology of CiliopathiesSemantic proximity Read ↗

Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease.Semantic proximity Read ↗

Cilia and polycystic kidney disease.Semantic proximity Read ↗

[Recent advances in molecular pathogenesis and treatment of polycystic kidney disease].Semantic proximity Read ↗

Molecular and cellular pathogenesis of autosomal recessive polycystic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.