Article

PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity

2026-06-29

Abstract excerpt

<h4>Abstract/Summary</h4> Human variants in renal polycystins (PKD1, PKD2) are responsible for most forms of autosomal dominant polycystic kidney disease (ADPKD), a common genetic disorder without curative drug treatment. Renal polycystins form ion channels in primary cilia, but our understanding of their molecular dysregulation caused by disease-associated variants is limited. Using cryo-electron microscopy (cry...

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Literature Corpus work: 9af9df7b-3cef-5b8c-9982-0373036588fe
DOI: 10.64898/2026.06.24.734313

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