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Exploring new potential role of DDB2 by host cell reactivation assay in human tumorigenic cells.

BMC cancer - 29 Oct 2019

Bassi Elisabetta, Perucca Paola, Guardamagna Isabella, Prosperi Ennio, Stivala Lucia A, Cazzalini Ornella

Abstract excerpt

BACKGROUND: The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verifying NER efficiency. Previously we have shown that DDB2, a protein involved in the Global Genome Repair, interacts directly with PCNA and, in human cells, the loss of this interaction affects DNA...

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Identifiers

PMID: 31664956
DOI: 10.1186/s12885-019-6258-0
PMCID: PMC6819583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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