Article
A damaged DNA binding protein 2 mutation disrupting interaction with proliferating-cell nuclear antigen affects DNA repair and confers proliferation advantage.
Biochimica et biophysica acta. Molecular cell research - 1 Jun 2018
Perucca Paola, Mocchi Roberto, Guardamagna Isabella, Bassi Elisabetta, Sommatis Sabrina, Nardo Tiziana, Prosperi Ennio, Stivala Lucia Anna, Cazzalini Ornella
Abstract excerpt
In mammalian cells, Nucleotide Excision Repair (NER) plays a role in removing DNA damage induced by UV radiation. In Global Genome-NER subpathway, DDB2 protein forms a complex with DDB1 (UV-DDB), recognizing photolesions. During DNA repair, DDB2 interacts directly with PCNA through a conserved region in N-terminal tail and this interaction is important for DDB2 degradation. In this work, we sought to investigate...
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