Article
Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants.
Journal of virology - 1 Aug 1997
Sitterlin D, Lee T H, Prigent S, Tiollais P, Butel J S, Transy C
Abstract excerpt
We carried out a comparative analysis of several proposed host protein partners of the human hepatitis B virus X protein (HBx) using both the GAL4- and the LexA-based yeast two-hybrid system. We showed that the interaction of HBx with the UV-damaged DNA-binding protein (UVDDB) is positive in both...
Topics
- Binding Sites
- DNA-Binding Proteins
- Hepadnaviridae
- Humans
- Mutation
- Trans-Activators
- Transcriptional Activation
- Ultraviolet Rays
- Viral Regulatory and Accessory Proteins