Article
Induction of a novel damage-specific DNA binding protein correlates with enhanced DNA repair in primate cells.
Molecular toxicology - 1 Jan 2000
Protić M, Hirschfeld S, Tsang A P, Wagner M, Dixon K, Levine A S
Abstract excerpt
Pretreatment of mammalian cell with DNA-damaging agents, such as UV light or mitomycin C, but not the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), results in the enhanced repair of subsequently transfected UV-damaged expression vectors. To determine the cellular factors that are responsible for this enhancement, we have used a modified gel retardation assay to detect the proteins that interact with...
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