Induction of a novel damage-specific DNA binding protein correlates with enhanced DNA repair in primate cells.

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Article

Induction of a novel damage-specific DNA binding protein correlates with enhanced DNA repair in primate cells.

Molecular toxicology - 1 Jan 2000

Protić M, Hirschfeld S, Tsang A P, Wagner M, Dixon K, Levine A S

Abstract excerpt

Pretreatment of mammalian cell with DNA-damaging agents, such as UV light or mitomycin C, but not the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA), results in the enhanced repair of subsequently transfected UV-damaged expression vectors. To determine the cellular factors that are responsible for this enhancement, we have used a modified gel retardation assay to detect the proteins that interact with...

Topics

Animals
Aphidicolin
Base Sequence
Blood
Cell Line
Culture Media
DNA Damage
DNA Repair
DNA-Binding Proteins
Diterpenes
Haplorhini
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitomycin

Mitomycins

Molecular Sequence Data

Phenotype

Plasmids

Tetradecanoylphorbol Acetate

Source

Open in PubMed

Identifiers

PMID: 2518795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2518795-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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