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Article

DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Cazzalini Ornella, Perucca Paola, Mocchi Roberto, Sommatis Sabrina, Prosperi Ennio, Stivala Lucia Anna

Abstract excerpt

DDB2 is a protein playing an essential role in the lesion recognition step of the global genome sub-pathway of nucleotide excision repair (GG-NER) process. Among the proteins involved in the DNA damage response, p21(CDKN1A) (p21) has been reported to participate in NER, but also to be removed by proteolytic degradation, thanks to its association with PCNA. DDB2 is involved in the CUL4-DDB1 complex mediating p21...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24200966
DOI: 10.4161/cc.26987
PMCID: PMC3906241

Genes

DDB2
PCNA
PIP
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.PMID 24200966Read ↗

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