Article
Expression of a transfected DNA repair gene (XPA) in xeroderma pigmentosum group A cells restores normal DNA repair and mutagenesis of UV-treated plasmids.
Carcinogenesis - 1 Jul 1995
Levy D D, Saijo M, Tanaka K, Kraemer K H
Abstract excerpt
The XPA gene was initially cloned based on the ability of its cDNA to improve survival of cells from xeroderma pigmentosum complementation group A (XP-A) patients following irradiation of the cells with UV. We used plasmid host cell reactivation assays to compare UV mutagenesis and the proficiency of DNA repair in a cell line from an XP-A patient, XP2OS(SV40), two derivative cell lines stably expressing XPA cDNAs...
Topics
- Base Sequence
- Cell Survival
- DNA Damage
- DNA Repair
- DNA, Complementary
- DNA-Binding Proteins
- Fibroblasts
- Gene Expression
- Genetic Markers
- Humans
- Molecular Sequence Data