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Article

Epithelial-to-mesenchymal transition and NF-kB pathways are promoted by a mutant form of DDB2, unable to bind PCNA, in UV-damaged human cells.

BMC cancer - 21 May 2024

Perucca Paola, Bassi Elisabetta, Vetro Martina, Tricarico Anna, Prosperi Ennio, Stivala Lucia Anna, Cazzalini Ornella

Abstract excerpt

BACKGROUND: DNA-Damaged Binding protein 2 (DDB2) is a protein involved in the early step of Nucleotide Excision Repair. Recently, it has been reported that DDB2 is involved in epithelial-to-mesenchymal transition (EMT), key process in tumour invasiveness and metastasis formation. However, its role is not completely known. METHODS: Boyden chamber and cell adhesion assays, and ICELLigence analysis were performed to...

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Identifiers

PMID: 38773406
DOI: 10.1186/s12885-024-12368-6
PMCID: PMC11110260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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