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Article

Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection

14 Oct 2019

Abstract excerpt

Early host responses toward pathogens are essential for defense against infection. In Caenorhabditis elegans , the transcription factor, SKN-1, regulates cellular defenses during xenobiotic intoxication and bacterial infection. However, constitutive activation of SKN-1 results in pleiotropic outcomes, including a redistribution of somatic lipids to the germline, which impairs health and shortens lifespan. Here,...

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PMID: 31611372
DOI: 10.1073/pnas.1909666116

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