Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.

International journal of molecular sciences - 22 Oct 2020

Lee Kiho, Escobar Iliana, Jang Yeeun, Kim Wooseong, Ausubel Frederick M, Mylonakis Eleftherios

Abstract excerpt

Sphingosine-1-phophate (S1P) is a sphingolipid-derived signaling molecule that controls diverse cellular functions including cell growth, homeostasis, and stress responses. In a variety of metazoans, cytosolic S1P is transported into the extracellular space where it activates S1P receptors in a concentration-dependent manner. In the free-living nematode Caenorhabditis elegans, the spin-2 gene, which encodes a S1P...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longevity

Share to Lysophospholipids

Share to p38 Mitogen-Activated Protein Kinases

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Pseudomonas aeruginosa

Share to Sphingosine

Source

Open in PubMed Open full text

Identifiers

PMID: 33105563
DOI: 10.3390/ijms21217813
PMCID: PMC7672543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria.PMID 33105563Read ↗

Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infectionSemantic proximity Read ↗

The purine nucleoside phosphorylase <i>pnp-1</i> regulates epithelial cell resistance to infection in <i>C. elegans</i>Semantic proximity Read ↗

The p38 MAPK/PMK-1 Pathway Is Required for Resistance to Nocardia farcinica Infection in Caenorhabditis eleganceSemantic proximity Read ↗

RACK-1, a multifaceted regulator is required for C. elegans innate immunity against S. flexneri M9OT infection.Semantic proximity Read ↗

Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathySemantic proximity Read ↗

Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathwaysSemantic proximity Read ↗

Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans.Semantic proximity Read ↗

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening.Semantic proximity Read ↗

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.Semantic proximity Read ↗

Sphingosine kinase SPHK-1 maintains sphingolipid metabolism to protect lysosome membrane integrity in C. elegans.Semantic proximity Read ↗

The Conserved G-Protein Coupled Receptor FSHR-1 Regulates Protective Host Responses to Infection and Oxidative Stress.Semantic proximity Read ↗

Within-species control reveals novel immune response genes in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.