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Article

Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans.

G3 (Bethesda, Md.) - 27 Jan 2016

Cheesman Hilary K, Feinbaum Rhonda L, Thekkiniath Jose, Dowen Robert H, Conery Annie L, Pukkila-Worley Read

Abstract excerpt

Inappropriate activation of innate immune responses in intestinal epithelial cells underlies the pathophysiology of inflammatory disorders of the intestine. Here we examine the physiological effects of immune hyperactivation in the intestine of the nematode Caenorhabditis elegans. We previously identified an immunostimulatory xenobiotic that protects C. elegans from bacterial infection by inducing immune effector...

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Source

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Identifiers

PMID: 26818074
DOI: 10.1534/g3.115.025650
PMCID: PMC4777117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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