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Article

A Caenorhabditis elegans spatiotemporal proximity atlas reveals the MAPK p38 as a generator of phenotypic plasticity in vivo.

Science signaling - 5 May 2026

Yuan Wang, Nunamaker Luke A, Weaver Yi M, Weaver Benjamin P

Abstract excerpt

Phenotypic plasticity, the ability to change diverse traits without altering genomic information, is fundamental for organismal adaptations to changing environments. The mitogen-activated protein kinase (MAPK) pathway plays a key role in cellular adaptations to changing environments. To analyze the contributions of the MAPK p38 and its interaction partners to phenotypic plasticity in an animal, we established an...

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Identifiers

PMID: 42085531
DOI: 10.1126/scisignal.aeb4530
PMCID: PMC13198063

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