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Article

A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.

Science (New York, N.Y.) - 26 Jul 2002

Kim Dennis H, Feinbaum Rhonda, Alloing Geneviève, Emerson Fred E, Garsin Danielle A, Inoue Hideki, Tanaka-Hino Miho, Hisamoto Naoki, Matsumoto Kunihiro, Tan Man-Wah, Ausubel Frederick M

Abstract excerpt

A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1, which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1, which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12142542
DOI: 10.1126/science.1073759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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