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Serotonin deficiency from constitutive SKN-1 activation drives pathogen apathy

16 Sept 2024

Abstract excerpt

When an organism encounters a pathogen, the host innate immune system activates to defend against pathogen colonization and toxic xenobiotics produced. C. elegans employ multiple defense systems to ensure survival when exposed to Pseudomonas aeruginosa including activation of the cytoprotective transcription factor SKN-1/NRF2. Although wildtype C. elegans quickly learn to avoid pathogens, here we describe a...

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PMID: 39285192
DOI: 10.1038/s41467-024-52233-5

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