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Article

Down-regulated RGS5 by genetic variants impairs endothelial cell function and contributes to coronary artery disease

4 Oct 2019

Abstract excerpt

AIMS: Genetic contribution to coronary artery disease (CAD) remains largely unillustrated. Although transcriptomic profiles have identified dozens of genes that are differentially expressed in normal and atherosclerotic vessels, whether those genes are genetically associated with CAD remains to be determined. Here, we combined genetic association studies, transcriptome profiles and in vitro and in vivo functional...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 31605122
DOI: 10.1093/cvr/cvz268

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