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Article

The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1.

PLoS genetics - 1 Jun 2022

Ma Lijiang, Bryce Nicole S, Turner Adam W, Di Narzo Antonio F, Rahman Karishma, Xu Yang, Ermel Raili, Sukhavasi Katyayani, d'Escamard Valentina, Chandel Nirupama, V'Gangula Bhargavi, Wolhuter Kathryn, Kadian-Dodov Daniella, Franzen Oscar, Ruusalepp Arno, Hao Ke, Miller Clint L, Björkegren Johan L M, Kovacic Jason C

Abstract excerpt

Genome wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of common disorders. However, since the large majority of these risk SNPs reside outside gene-coding regions, GWAS generally provide no information about causal mechanisms regarding the specific gene(s) that are affected or the tissue(s) in which these candidate gene(s) exert their...

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Identifiers

PMID: 35714152
DOI: 10.1371/journal.pgen.1010261
PMCID: PMC9246173

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