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Article

Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis

2 Apr 2024

Abstract excerpt

BACKGROUND: Pericytes are capillary-associated mural cells involved in the maintenance and stability of the vascular network. Although aging is one of the main risk factors for cardiovascular disease, the consequences of aging on cardiac pericytes are unknown. METHODS: In this study, we have combined single-nucleus RNA sequencing and histological analysis to determine the effects of aging on cardiac pericytes....

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PMID: 38563133
DOI: 10.1161/circresaha.123.324183

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