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Article

A Functional Polymorphism rs145204276 in the Promoter of Long Noncoding RNA GAS5 Is Associated with an Increased Risk of Ischemic Stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Dec 2018

Zheng Zhaoshi, Liu Songyan, Wang Chunhui, Han Xuemei

Abstract excerpt

Long noncoding RNAs (lncRNAs) play crucial roles in the regulation of pathological process of ischemic stroke (IS) via affecting cell apoptosis, inflammation, cell death, and angiogenesis. LncRNA growth arrest-specific 5 (GAS5) was observed to be up-regulated in IS, acting as a competing endogenous RNA for miR-137 to mediate the Notch1 signaling pathway. In this study, we aimed to whether an insertion/deletion...

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Identifiers

PMID: 30197169
DOI: 10.1016/j.jstrokecerebrovasdis.2018.08.016

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