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Article

Rgs5 targeting leads to chronic low blood pressure and a lean body habitus.

Molecular and cellular biology - 1 Apr 2008

Cho Hyeseon, Park Chung, Hwang Il-Young, Han Sang-Bae, Schimel Dan, Despres Daryl, Kehrl John H

Abstract excerpt

RGS5 is a potent GTPase-activating protein for G(ialpha) and G(qalpha) that is expressed strongly in pericytes and is present in vascular smooth muscle cells. To study the role of RGS5 in blood vessel physiology, we generated Rgs5-deficient mice. The Rgs5(-/-) mice developed normally, without obvious defects in cardiovascular development or function. Surprisingly, Rgs5(-/-) mice had persistently low blood...

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Source

Open in PubMed Open full text

Identifiers

PMID: 18268011
DOI: 10.1128/MCB.01889-07
PMCID: PMC2293121

Genes

RGS5
RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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