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Article

Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome-Wide Association Studies.

Journal of the American Heart Association - 7 Apr 2020

Li Yabo, Cho Hyosuk, Wang Fan, Canela-Xandri Oriol, Luo Chunyan, Rawlik Konrad, Archacki Stephen, Xu Chengqi, Tenesa Albert, Chen Qiuyun, Wang Qing Kenneth

Abstract excerpt

Background Epistasis describes how gene-gene interactions affect phenotypes, and could have a profound impact on human diseases such as coronary artery disease (CAD). The goal of this study was to identify gene-gene interactions in CAD using an easily generalizable multi-stage approach. Methods and Results Our forward genetic approach consists of multiple steps that combine statistical and functional approaches,...

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Share to Cardiovascular Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32237974
DOI: 10.1161/JAHA.119.014146
PMCID: PMC7428625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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