Article
Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation.
International journal of molecular sciences - 27 Feb 2021
Song Hui-Yung, Yang Yi-Ping, Chien Yueh, Lai Wei-Yi, Lin Yi-Ying, Chou Shih-Jie, Wang Mong-Lien, Wang Chien-Ying, Leu Hsin-Bang, Yu Wen-Chung, Chien Chian-Shiu
Abstract excerpt
The late-onset type of Fabry disease (FD) with GLA IVS4 + 919G > A mutation has been shown to lead to cardiovascular dysfunctions. In order to eliminate variations in other aspects of the genetic background, we established the isogenic control of induced pluripotent stem cells (iPSCs) for the identification of the pathogenetic factors for FD phenotypes through CRISPR/Cas9 genomic editing. We adopted droplet...
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