Article
Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.
PloS one - 1 Jan 2015
Matsukura Mitsuru, Ozaki Kouichi, Takahashi Atsushi, Onouchi Yoshihiro, Morizono Takashi, Komai Hiroyoshi, Shigematsu Hiroshi, Kudo Toshifumi, Inoue Yoshinori, Kimura Hideo, Hosaka Akihiro, Shigematsu Kunihiro, Miyata Teturo, Watanabe Toshiaki, Tsunoda Tatsuhiko, Kubo Michiaki, Tanaka Toshihiro
Abstract excerpt
Characteristics of peripheral arterial disease (PAD) are the occlusion or stenosis of multiple vessel sites caused mainly by atherosclerosis and chronic lower limb ischemia. To identify PAD susceptible loci, we conducted a genome-wide association study (GWAS) with 785 cases and 3,383 controls in a Japanese population using 431,666 single nucleotide polymorphisms (SNP). After staged analyses including a total of...
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