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Article

Widespread Historical Contingency in Influenza Viruses.

Genetics - 1 Jan 2017

Nshogozabahizi Jean Claude, Dench Jonathan, Aris-Brosou Stéphane

Abstract excerpt

In systems biology and genomics, epistasis characterizes the impact that a substitution at a particular location in a genome can have on a substitution at another location. This phenomenon is often implicated in the evolution of drug resistance or to explain why particular "disease-causing" mutations do not have the same outcome in all individuals. Hence, uncovering these mutations and their locations in a genome...

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Identifiers

PMID: 28049709
DOI: 10.1534/genetics.116.193979
PMCID: PMC5223518

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