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Article

A clonal expression biomarker associates with lung cancer mortality

1 Oct 2019

Abstract excerpt

An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types2–6. Here, we analyze multi-region whole-exome and RNA sequencing data for 156...

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PMID: 31591602
DOI: 10.1038/s41591-019-0595-z

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