Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.

doi:10.1126/science.1256930

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Article

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.

Science (New York, N.Y.) - 10 Oct 2014

Zhang Jianjun, Fujimoto Junya, Zhang Jianhua, Wedge David C, Song Xingzhi, Zhang Jiexin, Seth Sahil, Chow Chi-Wan, Cao Yu, Gumbs Curtis, Gold Kathryn A, Kalhor Neda, Little Latasha, Mahadeshwar Harshad, Moran Cesar, Protopopov Alexei, Sun Huandong, Tang Jiabin, Wu Xifeng, Ye Yuanqing, William William N, Lee J Jack, Heymach John V, Hong Waun Ki, Swisher Stephen, Wistuba Ignacio I, Futreal P Andrew

Abstract excerpt

Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We applied multiregion whole-exome sequencing (WES) on 11 localized lung adenocarcinomas. All tumors showed clear evidence of ITH. On average, 76% of all mutations and 20 out of 21 known cancer gene mutations were...

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PMID: 25301631
DOI: 10.1126/science.1256930
PMCID: PMC4354858

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