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Article

Intratumoral genetic and immune microenvironmental heterogeneity in T4N0M0 (diameter ≥ 7 cm) non-small cell lung cancers.

Thoracic cancer - 1 May 2022

Zhang Jia Tao, Dong Song, Ji Li Yan, Zhou Jia Ying, Chen Zhi Hong, Su Jian, Zhu Qing Ge, Wang Meng Min, Ke E E, Sun Hao, Li Xue Tao, Yang Jin Ji, Zhou Qing, Zhang Xu Chao, Gao Xuan, Yang Xue Ning, Xia Xuefeng, Yi Xin, Zhong Wen Zhao, Wu Yi Long

Abstract excerpt

BACKGROUND: Starting with low metastatic capability, T4N0M0 (diameter ≥ 7 cm) non-small cell lung cancers (NSCLCs) constitute a unique tumor subset, as with a large tumor size but no regional or distant metastases. We systematically investigated intratumoral heterogeneity, clonal structure, chromosomal instability (CIN), and immune microenvironment in T4N0M0 (≥7 cm) NSCLCs. METHODS: Whole-exome sequencing, RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35394115
DOI: 10.1111/1759-7714.14393
PMCID: PMC9058296

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