Article
Genomic-transcriptomic evolution in lung cancer and metastasis.
Nature - 1 Apr 2023
Martínez-Ruiz Carlos, Black James R M, Puttick Clare, Hill Mark S, Demeulemeester Jonas, Larose Cadieux Elizabeth, Thol Kerstin, Jones Thomas P, Veeriah Selvaraju, Naceur-Lombardelli Cristina, Toncheva Antonia, Prymas Paulina, Rowan Andrew, Ward Sophia, Cubitt Laura, Athanasopoulou Foteini, Pich Oriol, Karasaki Takahiro, Moore David A, Salgado Roberto, Colliver Emma, Castignani Carla, Dietzen Michelle, Huebner Ariana, Al Bakir Maise, Tanić Miljana, Watkins Thomas B K, Lim Emilia L, Al-Rashed Ali M, Lang Danny, Clements James, Cook Daniel E, Rosenthal Rachel, Wilson Gareth A, Frankell Alexander M, de Carné Trécesson Sophie, East Philip, Kanu Nnennaya, Litchfield Kevin, Birkbak Nicolai J, Hackshaw Allan, Beck Stephan, Van Loo Peter, Jamal-Hanjani Mariam, Swanton Charles, McGranahan Nicholas
Abstract excerpt
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy1. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study2,3. Analyses of 947 tumour regions, representing both primary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.