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Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma

9 Jan 2025

Abstract excerpt

Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39789179
DOI: 10.1038/s43018-024-00883-1

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