Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors.

Cell reports - 19 Nov 2019

Sharma Anchal, Merritt Elise, Hu Xiaoju, Cruz Angelique, Jiang Chuan, Sarkodie Halle, Zhou Zhan, Malhotra Jyoti, Riedlinger Gregory M, De Subhajyoti

Abstract excerpt

Impacts of genetic and non-genetic intra-tumor heterogeneity (ITH) on tumor phenotypes and evolvability remain debated. We analyze ITH in lung squamous cell carcinoma at the levels of genome, transcriptome, and tumor-immune interactions and histopathological characteristics by multi-region bulk and single-cell sequencing. Genomic heterogeneity alone is a weak indicator of intra-tumor non-genetic heterogeneity at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Cell Proliferation

Share to High-Throughput Nucleotide Sequencing

Share to Inflammation

Share to Lung Neoplasms

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 31747591
DOI: 10.1016/j.celrep.2019.10.045
PMCID: PMC6952742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors.PMID 31747591Read ↗

Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and ProgressionSemantic proximity Read ↗

Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancerSemantic proximity Read ↗

Intratumoral heterogeneity and clonal evolution in liver cancer.Semantic proximity Read ↗

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages.Semantic proximity Read ↗

Mechanisms of Progression and Heterogeneity in Multiple Nodules of Lung AdenocarcinomaSemantic proximity Read ↗

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stagesSemantic proximity Read ↗

Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival.Semantic proximity Read ↗

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung AdenocarcinomaSemantic proximity Read ↗

Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on SurvivalSemantic proximity Read ↗

Drivers of dynamic intratumor heterogeneity and phenotypic plasticity.Semantic proximity Read ↗

Tumor Heterogeneity and the Immune Response in Non-Small Cell Lung Cancer: Emerging Insights and Implications for ImmunotherapySemantic proximity Read ↗

Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on SurvivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.