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Article

Intratumoral heterogeneity as a potential biomarker for immunotherapy response and postoperative recurrence in NSCLC.

Frontiers in immunology - 1 Jan 2026

Wang Yuhang, Dong Xiaoying, Yin Yucheng, Lin Zuju, Ren Pengfei, Zheng Yating, Wang Haofei

Abstract excerpt

Background: Intratumoral heterogeneity (ITH) is associated with poor prognosis in various solid tumors. However, its use as a predictive biomarker for immunotherapy in advanced non-small cell lung cancer (NSCLC) is still lacking. Methods: We used Maftools to analyze somatic variants of NSCLC from independent cohorts (POPLAR, OAK, Hellmann2018) including 504 patients with advanced NSCLC. Additionally, 121 patients...

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Identifiers

PMID: 42643285
DOI: 10.3389/fimmu.2026.1852284
PMCID: PMC13503312

Genes

CD4
SHOX2

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