Article
Tracking the Evolution of Non-Small-Cell Lung Cancer.
The New England journal of medicine - 1 Jun 2017
Jamal-Hanjani Mariam, Wilson Gareth A, McGranahan Nicholas, Birkbak Nicolai J, Watkins Thomas B K, Veeriah Selvaraju, Shafi Seema, Johnson Diana H, Mitter Richard, Rosenthal Rachel, Salm Max, Horswell Stuart, Escudero Mickael, Matthews Nik, Rowan Andrew, Chambers Tim, Moore David A, Turajlic Samra, Xu Hang, Lee Siow-Ming, Forster Martin D, Ahmad Tanya, Hiley Crispin T, Abbosh Christopher, Falzon Mary, Borg Elaine, Marafioti Teresa, Lawrence David, Hayward Martin, Kolvekar Shyam, Panagiotopoulos Nikolaos, Janes Sam M, Thakrar Ricky, Ahmed Asia, Blackhall Fiona, Summers Yvonne, Shah Rajesh, Joseph Leena, Quinn Anne M, Crosbie Phil A, Naidu Babu, Middleton Gary, Langman Gerald, Trotter Simon, Nicolson Marianne, Remmen Hardy, Kerr Keith, Chetty Mahendran, Gomersall Lesley, Fennell Dean A, Nakas Apostolos, Rathinam Sridhar, Anand Girija, Khan Sajid, Russell Peter, Ezhil Veni, Ismail Babikir, Irvin-Sellers Melanie, Prakash Vineet, Lester Jason F, Kornaszewska Malgorzata, Attanoos Richard, Adams Haydn, Davies Helen, Dentro Stefan, Taniere Philippe, O'Sullivan Brendan, Lowe Helen L, Hartley John A, Iles Natasha, Bell Harriet, Ngai Yenting, Shaw Jacqui A, Herrero Javier, Szallasi Zoltan, Schwarz Roland F, Stewart Aengus, Quezada Sergio A, Le Quesne John, Van Loo Peter, Dive Caroline, Hackshaw Allan, Swanton Charles
Abstract excerpt
BACKGROUND: Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome and to determine the clonal nature of driver events and evolutionary processes in early-stage NSCLC. METHODS: In this prospective cohort...
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