Article
Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival.
Oncotarget - 1 Mar 2016
Morris Luc G T, Riaz Nadeem, Desrichard Alexis, Şenbabaoğlu Yasin, Hakimi A Ari, Makarov Vladimir, Reis-Filho Jorge S, Chan Timothy A
Abstract excerpt
As tumors accumulate genetic alterations, an evolutionary process occurs in which genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic heterogeneity (ITH). The clinical implications of ITH remain poorly defined. Data are limited with respect to whether ITH is an independent determinant of patient survival outcomes, across different cancer types. Here, we report the results...
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