Clonal Architecture of EGFR Mutation Predicts the Efficacy of EGFR-Tyrosine Kinase Inhibitors in Advanced NSCLC: A Prospective Multicenter Study (NCT03059641).

doi:10.1158/1078-0432.CCR-20-3063

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Article

Clonal Architecture of EGFR Mutation Predicts the Efficacy of EGFR-Tyrosine Kinase Inhibitors in Advanced NSCLC: A Prospective Multicenter Study (NCT03059641).

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2021

Ai Xinghao, Cui Jiuwei, Zhang Jiexia, Chen Rongrong, Lin Wen, Xie Congying, Liu Anwen, Zhang Junping, Yang Weihua, Hu Xiaohua, Hu Xiaohua, Zhao Qiong, Rao Chuangzhou, Zang Yuan-Sheng, Ning Ruiling, Li Pansong, Chang Lianpeng, Yi Xin, Lu Shun

Abstract excerpt

PURPOSE: Clonal architecture is fundamental for the understanding of cancer biology and therapy; however, multiregional sampling in advanced-stage cancers is not always applicable. This prospective clinical trial was to investigate whether paired tissue and circulating tumor DNA (ctDNA) could describe the clonal architecture of advanced non-small cell lung cancer (NSCLC) and its association with clinical outcome...

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PMID: 33188140
DOI: 10.1158/1078-0432.CCR-20-3063

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