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Article

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APPswe/PS1ΔE9 Transgenic Mice

30 Jul 2019

Abstract excerpt

Insulin-like growth factor-1 (IGF-1) is a pleiotrophic molecule with neurotrophic and immunomodulatory functions. Knowing the capacity of chronically activated microglia to produce IGF-1 may therefore show essential to promote beneficial microglial functions in Alzheimer’s disease. Here, we investigated the expression of IGF-1 mRNA along with the expression of tumor necrosis factor (TNF) mRNA, and the amyloid-β...

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Identifiers

PMID: 31417357
DOI: 10.3389/fncel.2019.00308

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