Article
Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2006
Butovsky Oleg, Koronyo-Hamaoui Maya, Kunis Gilad, Ophir Eran, Landa Gennady, Cohen Hagit, Schwartz Michal
Abstract excerpt
Alzheimer's disease (AD) is characterized by plaque formation, neuronal loss, and cognitive decline. The functions of the local and systemic immune response in this disease are still controversial. Using AD double-transgenic (APP/PS1) mice, we show that a T cell-based vaccination with glatiramer acetate, given according to a specific regimen, resulted in decreased plaque formation and induction of neurogenesis....
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