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Article

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Mar 2013

Ghosh Simantini, Wu Michael D, Shaftel Solomon S, Kyrkanides Stephanos, LaFerla Frank M, Olschowka John A, O'Banion M Kerry

Abstract excerpt

Neuroinflammation is an important component of Alzheimer's disease (AD) pathogenesis and has been implicated in neurodegeneration. Interleukin-1 (IL-1), a potent inflammatory cytokine in the CNS, is chronically upregulated in human AD and believed to serve as part of a vicious inflammatory cycle that drives AD pathology. To further understand the role of IL-1β in AD pathogenesis, we used an inducible model of...

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Identifiers

PMID: 23486975
DOI: 10.1523/JNEUROSCI.4361-12.2013
PMCID: PMC3637949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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