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Article

Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: a study in APP mutant mice.

Neuroscience letters - 6 Jan 2012

Luccarini Ilaria, Grossi Cristina, Traini Chiara, Fiorentini Anna, Ed Dami Teresa, Casamenti Fiorella

Abstract excerpt

The purpose of this study was to investigate the microglia-driven apoptosis and the Aβ deposits triggered generation of new microglial cells in the neocortex of TgCRND8 mice. Three- and seven-month-old TgCRND8 mice, displaying an early and widespread amyloid deposition, respectively, were used. In 7-month-old TgCRND8 mice the Aβ-associated glial reaction was accompanied by an intense immunoreactivity of both...

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Source

Identifiers

PMID: 22056484
DOI: 10.1016/j.neulet.2011.10.056

Genes

APP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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