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Article

Abrogation of type-I interferon signalling alters the microglial response to Aβ1-42.

Scientific reports - 21 Feb 2020

Moore Zachery, Mobilio Frank, Walker Frederick R, Taylor Juliet M, Crack Peter J

Abstract excerpt

Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines. Efforts to phenotypically characterize microglia within AD identify distinct populations associated with type-I IFN signalling, yet how this affects underlying microglial function is...

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Identifiers

PMID: 32081950
DOI: 10.1038/s41598-020-59917-0
PMCID: PMC7035268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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