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Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease

11 Mar 2005

Abstract excerpt

BACKGROUND: Inflammation is believed to play an important role in the pathology of Alzheimer's disease (AD) and cytokine production is a key pathologic event in the progression of inflammatory cascades. The current study characterizes the cytokine expression profile in the brain of two transgenic mouse models of AD (TgAPPsw and PS1/APPsw) and explores the correlations between cytokine production and the level of...

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PMID: 15762998
DOI: 10.1186/1742-2094-2-9

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